Postdoctoral Research Associate
Research Interests:
Prostate cancer cells has unique metabolic phenotype, however, comprehensive understating of the metabolic reprogramming in prostate cancer is not available. We have observed that pharmaceutical inhibitors such as (R)-9b affects prostate cancer cells metabolism, which contribute to attenuated growth of cancer cells. Surbhi is investigating re-structuring of metabolic networks in prostate cancer cells which impart them selective metabolic advantage over normal prostate cells and exploring reverting onco-metabolic alterations.
Another aspect she is examining is the how kinase-phosphatase interaction plays its role in various malignancies, especially role of this signaling nexus in epigenetic regulation of global transcription.
Selected Publications:
- Chouhan S, Sawant M, Weimholt C, Luo J, Sprung RW, Terrado M, Mueller DM, Earp HS and Mahajan NP*. ACK1/TNK2 Mediated Phosphorylation of ATP Synthase α-Subunit Selectively Augments Survival of Prostate Cancer While Engendering Mitochondrial Vulnerability. Autophagy, 2022.
- Sridaran D, Chouhan S, Mahajan K, Bhagwat S, Reimers M, Kim E, Thakur M, Pachynski R, Seeliger M, Miller T, Feng F and Mahajan NP*. Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nature Communications, 2022.
- Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, Li T, Koomen J, Fang B, Putluri N, Sreekumar A, Feng FY, Mahajan K & Mahajan NP*. Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer. Nature Communications, 14, Article number: 3357, 2023.
- Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson MC, Santos LN, Sommer SL, Fang B, Koomen JM, Qu C-K, Yart A, Kontaridis MI, Mahajan NP*. SHP2 phosphatase in androgen receptor signaling. Nature Communications, under revision, 2023.
Surbhi Chouhan
M.Sc. Devi Ahilya University
PhD, Pune University
Contact:
Email:chouhan.surbhi@wustl.edu
Phone: 314-273-7759