Postdoctoral Research Associate
Prostate cancer cells has unique metabolic phenotype, however, comprehensive understating of the metabolic reprogramming in prostate cancer is not available. We have observed that pharmaceutical inhibitors such as (R)-9b affects prostate cancer cells metabolism, which contribute to attenuated growth of cancer cells. Surbhi is investigating re-structuring of metabolic networks in prostate cancer cells which impart them selective metabolic advantage over normal prostate cells and exploring reverting onco-metabolic alterations.
Another aspect she is examining is the how kinase-phosphatase interaction plays its role in various malignancies, especially role of this signaling nexus in epigenetic regulation of global transcription.
- Chouhan S, Sawant M, Weimholt C, Luo J, Sprung RW, Terrado M, Mueller DM, Earp HS and Mahajan NP*. ACK1/TNK2 Mediated Phosphorylation of ATP Synthase α-Subunit Selectively Augments Survival of Prostate Cancer While Engendering Mitochondrial Vulnerability. Autophagy, 2022.
- Sridaran D, Chouhan S, Mahajan K, Bhagwat S, Reimers M, Kim E, Thakur M, Pachynski R, Seeliger M, Miller T, Feng F and Mahajan NP*. Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nature Communications, 2023
- Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Feng F, Mahajan NP*. Epigenetic Control of Androgen Production by Histone acetylation. Nature Communications. 2023. (In Revision).
- Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson MC, Santos LN, Sommer SL, Fang B, Koomen JM, Qu C-K, Yart A, Kontaridis MI, Mahajan NP*. SHP2 phosphatase in androgen receptor signaling. 2023.
M.Sc. Devi Ahilya University
PhD, Pune University