Postdoctoral Research Associate
Research Interests:
An important aspect of prostate cancer cells is its unique metabolic phenotype, which has become a new are of research exploration. However, comprehensive understating of the metabolic reprogramming in prostate cancer is not available. We have observed that pharmaceutical inhibitors such as (R)-9b affects prostate cancer cells metabolism, which contribute to attenuated growth of cancer cells. Surbhi is investigating re-structuring of metabolic networks in prostate cancer cells which impart them selective metabolic advantage over normal prostate cells and exploring reverting onco-metabolic alterations.
Another aspect she is examining is the how kinase-phosphatase interaction plays its role in prostate malignancy, especially role of this signaling nexus in epigenetic regulation of global transcription.
Selected Publications:
- Chouhan S, Sawant M, Weimholt C, Luo J, Sprung RW, Terrado M, Mueller DM, Earp HS and Mahajan NP*. ACK1/TNK2 Mediated Phosphorylation of ATP Synthase α-Subunit Selectively Augments Survival of Prostate Cancer While Engendering Mitochondrial Vulnerability. Autophagy. 2022
- Sridaran D, Chouhan S, Mahajan K, Rengarajan A, Bhagwat S, Reimers M, Kim E, Thakur M, Pachynski R, Seeliger M, Miller T, Feng F and Mahajan NP*. Parallel Host T Cell Reinvigoration and Augmentation of Leukocyte Attractant by Cancer Cell Upon ACK1 inhibition Overcomes Immune Resistance. 2022.
- Kumari R*, Chouhan S*, Singh S*, Chhipa R R, Ajay A K and Bhat MK. Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. Journal of Bioscience, 42(1):31-41. 2017.
Surbhi Chouhan
M.Sc. Devi Ahilya University
PhD, Pune University
Contact:
Email:chouhan.surbhi@wustl.edu
Phone: 314-273-7759