A major interest of our lab is to determine how tyrosine phosphorylation regulates epigenetic processes that affect cellular homeostasis, immune impairment and cancer cell survival. We employ multiple kinases & phosphatases:

ACK1 (TNK2) : An oncogene with epigenetic activity in prostate, breast & lung cancers

WEE1 : A novel epigenetic modulator & its significance in various malignancies

Major findings of our lab include:

  • Discovered 3 new epigenetic events:
    • Y88-Phosphorylation of histone H4
    • Y37-Phosphorylation of histone H2B
    • Y99-Phosphorylation of histone H3
  • Identified a novel lncRNA, NXTAR that regulated expression of AR
  • Developed a new class of a small molecule inhibitor for ACK1, (R)-9b
  • Identified a novel WEE1 epigenetic inhibitor
  • Identified a novel AKT Tyr176-phosphorylation that causes AKT activation
  • Identified novel AR Lys609-acetylation
  • Identified a new class of KDM6 inhibitor
Mahajan K et al, J Cell Physiol. 224:327-333, 2010

Startup

These studies led to establishment of TechnoGenesys, Inc., a startup focusing on new cancer drugs.

Current Projects in Lab

  • Epigenetic signaling in dampening immune cells response to tumors
  • Characterization of novel WEE1 and KDM6 inhibitors
  • LncRNA as Androgen receptor regulator and therapeutic strategy

Graduate Student Opportunities

We are accepting graduate students from DBBS (Cancer Biology, Molecular Genetics & Genomics, Molecular Cell Biology, Human & statistical Genetics) and Dept of Biomedical Engineering. Contact: nupam@wustl.edu

Postdoctoral Opportunities

We are in recruitment drive. Send your CV to: nupam@wustl.edu

Nupam Mahajan, PhD

Department of Surgery Faculty Profile

Professor of Surgery
Endowed Professor of Cancer Research
Director of Urological Research

Contact:
Washington University

Email:nupam@wustl.edu

Phone: 
Office: 314-273-7727 
Lab: 314-273-7759
Fax: 314-272-7771 

Funding Sources:

  • National Institute of Health (NIH)
  • Congressionally Directed Medical Research Programs (CDMRP)
  • Bankhead-Coley Florida Biomedical Research Program
  • Elsa U. Pardee Foundation
  • National Cancer Institute (NCI)
  • Prostate Cancer Foundation (PCF)
  • Celgene – Committed to improving the lives of patients worldwide