Postdoctoral Research Fellow
Research Interests:
Dhivya’s research interests are cellular signaling and deregulation in carcinogenesis and identification of novel molecular targets for translation research. She is presently working on the mechanistic insights of tyrosine kinases specifically, WEE1 and ACK1 in cancer development and progression. The study aims to identify and assess WEE1 kinase mediated epigenetic regulation and molecular alterations in prostate cancer. Novel small molecule inhibitors developed to target WEE1 are also assessed for their therapeutic potential as independent drugs for cancer treatment. Knock-out mice model is used to assess the functional significance of ACK1 as a central regulator of cellular homeostasis.
Selected Publications:
1. Sridaran D, Chouhan S, Mahajan K, Renganathan A, Bhagwat S, Reimers M, Kim EH, Thakur MK, Saeed MA, Pachynski RK, Seeliger M, Miller TW, Feng FY, Mahajan NP*. Parallel Host T Cell Reinvigoration and Augmentation of Leukocyte Attractant by Cancer Cell Upon ACK1 inhibition Overcomes Immune Resistance. Nature Communications (In Revision), 2022.
2. Nguyen T, Sridaran D, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, Felix Y. Feng, Nupam P. Mahajan. Regulation of Androgen Production in prostate tumors and effect on immune cells. 2022.
3. Dhivya S, Premkumar K (2016). Nomadic genetic elements contribute to oncogenic translocations: Implications in carcinogenesis. Crit. Rev. Oncol/Hematol. 98:81–93.
Dhivya Sridaran
MSc, VIT University
PhD, Bharathidasan University
Contact:
Email: dhivyasridaran@wustl.edu
Phone: 314 273-7759