Postdoctoral Research Associate
Research Interests:
Genomic alterations in Androgen Receptor
Androgen receptor (AR), plays a crucial role in prostate cancer progression to a highly metastatic Castration Resistant Prostate cancer (CRPC). We identified previously unknown acetylation site, K609 in AR DNA binding domain. Jagat’s research focuses on unraveling genomic alteration in AR and other genes upon initiation and progression of prostate cancer using various models.
Exploring (R)-9b, a small molecular inhibitor of ACK1, in drug-resistant Breast Cancer
We have designed an inhibitor of ACK1, (R)-9b, which potently inhibits prostate cancer and breast cancer growth. Current studies are aimed to validate whether (R)-9b could overcome CDK4/6 inhibitor, palbociclib-resistant breast tumor growth.
Selected Publications:
- Rei Yoshimoto, Jagat K Chhipi-Shrestha, Tilman Schneider-Poetsch, Masaaki Furuno, Shintaro Iwasaki, Minoru Yoshida. Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation. Cell Chem Biol. 2021 Sep 16;28(9):1356-1365.
- Jagat K. Chhipi-Shrestha, Tilman Schneider-Poetsch, Takehiro Suzuki, …, Naoshi Dohmae, Shintaro Iwasaki, Minoru Yoshida. Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns. Cell Chem Biol. 29, 259–275, 2022.
Jagat krishna Chhipi Shrestha
M.Sc., Tribhuvan University, Kathmandu, Nepal
Ph.D., Chemical Genomics Research, RIKEN, Wako, Saitama, Japan
Contact:
Email: cjagat@wustl.edu
Phone: 314-273-7759