Postdoctoral Research Associate

Research Interests:

Post-translational modifications in Androgen Receptor and their contributions to prostate & breast tumorigenesis

Androgen receptor (AR), plays a crucial role in prostate cancer progression to a highly metastatic Castration Resistant Prostate cancer (CRPC). We identified previously unknown modification site in AR DNA binding domain. My research focuses on unraveling this occurrence as well as exploring its implications in resistance. 

Exploring (R)-9b, a small molecular inhibitor of ACK1, in drug-resistant Breast Cancer

We have established a positive correlation between the expression of activated ACK1 and breast cancers. Exploring ACK1 and its downstream effectors as a plausible hit to circumvent the problem of lack of expression of targetable receptors may provide clinical benefits. We have designed a small molecular inhibitor of ACK1, (R)-9b, which has shown to be potent against prostate cancer and TNBCs. Current studies are aimed to validate whether abolishing the ACK1 addiction of breast cancers using ACK1 inhibitors could serve as prospective therapeutic intervention, as well as to certify the candidature of (R)-9b as a potential anti-cancer agent.

Selected Publications:

  1. Sawant M, Mahajan K, Renganathan A, Weimholt C, Luo J, Kukshal V, Jez JM, Jeon MS, Zhang B, Li T, Fang B, Lawrence NJ, Luo Y,  Lawrence HR, Feng FY, and Mahajan NP*. Chronologically modified androgen receptor in recurrent castration resistant prostate cancer and its therapeutic targeting. Science Translational Medicine, 2022.
  2. Ghildiyal R, Sawant M, Renganathan A, Kim E, Luo J, Mahajan K, Feng F and Mahajan NP*. Loss of long non-coding RNA NXTAR in prostate cancer augments androgen receptor expression and enzalutamide resistance. Cancer Research, 82(1):155-168, 2022
  3. Sawant M, Wilson A, Mahajan K, Christopher O’Conor, Ian Hagemann, Jingqin Luo, Tiandao Li, Juan Carlos Roa,  Xinyan Wu, Akhilesh Pandey, Mahajan NP*. ACK1/TNK2 Epigenetically Regulates Cell Cycle Program to Promote Breast Cancer. 2022

Mithila Sawant

M. Sc.,  Mumbai University

Ph.D.,  Pune University

Contact:

Email:mithila.s@wustl.edu

Phone: 314-273-7759