The lab theme is to determine how tyrosine kinases, phosphatases, demethylases and nuclear receptors regulates epigenetic processes that affect cellular homeostasis, immune impairment and cancer. We employ:
ACK1 (TNK2): Immune modulator and oncogene
WEE1: A novel epigenetic modulator
SHP2 (PTPN11): Role in cancer and LEOPARD syndrome
Androgen Receptor (AR): Prostate cancer and immunity
KDM6A (UTX): Role in Multiple sclerosis and aging
Major findings of our lab include:
- Discovered 7 new epigenetic events:
- Y88-Phosphorylation of histone H4
- Y37-Phosphorylation of Histone H2B
- Y54-Phosphorylation of Histone H3
- K130-acetylatylation of Histone H2A
- Y-Phosphorylation of histone H2A
- Y99-Phosphorylation of histone H3
- Identified 3 new Inhibitors
- ACK1 inhibitor, (R)-9b
- WEE1 inhibitor
- KDM6A inhibitor
- Identified a novel lncRNA, NXTAR
- Identified AKT Tyr176-phosphorylation
- Identified AR Lys609-acetylation
Startup
These studies led to establishment of TechnoGenesys, Inc., focusing on ACK1 inhibitor as an anti-cancer drug.
Current Projects in Lab
- Epigenetic signaling in dampening of immune response to tumors
- Characterization of new subsets of T, B cells and neutrophils
- Androgen regulated immune response
- KDM6A inhibitor in overcoming autoimmune disorders
- New class of WEE1 inhibitors
Graduate Student Opportunities
We are accepting graduate students from DBBS (Cancer Biology, Molecular Genetics & Genomics, Molecular Cell Biology, Human & statistical Genetics) and Dept of Biomedical Engineering. Contact: nupam@wustl.edu
Postdoctoral Opportunities
We are in recruitment drive. Send your CV to: nupam@wustl.edu
Nupam Mahajan, PhD
Department of Surgery Faculty Profile
Professor of Surgery
Endowed Professor of Cancer Research
Director of Urological Research
Contact:
Washington University, St Louis
Email: nupam@wustl.edu
Phone:
Office: 314-273-7727
Lab: 314-273-7759
Fax: 314-272-7771
Funding Sources:
- National Institute of Health (NIH)/NCI
- R01 CA276502
- R01 CA273054
- R01 CA285526
- R01 CA286443
- Congressionally Directed Medical Research Programs (CDMRP)
- Bankhead-Coley Biomedical Research Program
- Elsa U. Pardee Foundation
- Prostate Cancer Foundation (PCF)
- Celgene – Committed to improving the lives of patients worldwide